What we do..We are located at BJCIH (Medical School Campus) as a part of Department of Pahology&Immunology. Our lab is also a part Center Biological Systems Engineering (Danforth Campus).
Our research is on the cross-roads between experiments and theory/computation and can be characterized most succinctly as Systems Immunology whereby we use various methods for unbiased data generation (e.g. high-throughput next-generation sequencing) in conjunction with mathematical and statistical modeling approaches.
We focus on developing integrated experimental and computational pipelines to address important biological problems by leveraging the power of next-generation sequencing. Two major components comprise creation of such integrated pipeline: first, optimization of sequencing library preparation protocols to achieve high-throughput and cost affordability, and, second, corresponding bioinformatic processing of sequencing data and computational analysis of the high-throughput gene-expression and other kinds of sequencing data (e.g. ChipSeq, RACE etc) that allow one to gain insight into the biology in hand.
Our major interests are in the fields of Immunometabolism, Epigenetic and Transcriptional regulation associated with immune activation in the context of infectious diseases, cancer and aging.